Status: Complete
Prevent Clot
PREVENTion of Clot in Orthopaedic Trauma (PREVENT CLOT): A Randomized Pragmatic Trial Comparing the Complications and Safety of Blood Clot Prevention Medicines Used in Orthopaedic Trauma Patients
Projected dates of study: Oct 2016 — May 2023
Clinical PI: Robert O'Toole, MD
MCC PI: Renan Castillo, PhD
Study Info
- 12,211 Patients
- Patients Enrolled
- 5 Publications
- Articles Published
- 19 Sites
- Sites Participated
- 97%
- Follow Up
Participating Sites (19)
- Allegheny Hospital
- Carolinas Medical Center
- Dartmouth-Hitchcock Medical Center
- Harvard Orthopaedic Trauma Service
- Inova Fairfax Hospital
- Methodist Hospital
- MetroHealth Medical Center
- Rhode Island Hospital Brown University
- San Antonio Military Medical Center
- University of Maryland R Adams Cowley Shock Trauma Center
- University of Miami Ryder Trauma Center
- University of Mississippi Medical Center
- University of Tennessee Chattanooga
- University of Texas Houston
- University of Washington Harborview Medical Center
- University of Wisconsin
- Vanderbilt University Medical Center
- Wakeforest University Baptist Medical Center
Publications
Journals & Articles
- O'Hara NN, Frey KP, Stein DM, Levy JF, Slobogean GP, Castillo R, Firoozabadi R, Karunakar MA, Gary JL, Obremskey WT, Seymour RB, Cuschieri J, Mullins CD, O'Toole RV; METRC. Effect of Aspirin Versus Low-Molecular-Weight Heparin Thromboprophylaxis on Medication Satisfaction and Out-of-Pocket Costs: A Secondary Analysis of a Randomized Clinical Trial. J Bone Joint Surg Am. 2024 Apr 3;106(7):590-599. doi: 10.2106/JBJS.23.00824. Epub 2024 Feb 21. PMID: 38381842; PMCID: PMC10980176.
- https://pubmed.ncbi.nlm.nih.gov/38381842/
- URL
- O'Hara NN, O'Toole RV, Frey KP, Castillo RC, Cuschieri J, Haut ER, Slobogean GP, Firoozabadi R, Christmas A, Obremskey WT, Carlini AR, Gaski G, Kutcher ME, Marvel D, Stein DM; Major Extremity Trauma Research Consortium (METRC). Risk-stratified thromboprophylaxis effects of aspirin versus low-molecular-weight heparin in orthopaedic trauma patients: a secondary analysis of the PREVENT CLOT trial. J Trauma Acute Care Surg. 2023 Dec 8. doi: 10.1097/TA.0000000000004226. Epub ahead of print. PMID: 38079260.
- https://pubmed.ncbi.nlm.nih.gov/38079260/
- URL
- Major Extremity Trauma Research Consortium (METRC). Aspirin or low-molecular-weight heparin for thromboprophylaxis after a fracture. N Engl J Med 2023;388:203-13.
- https://pubmed.ncbi.nlm.nih.gov/36652352/
- URL
- O'Toole RV, Stein DM, Frey KP, O'Hara NN, Scharfstein DO, Slobogean GP, Taylor TJ, Haac BE, Carlini AR, Manson TT, Sudini K, Mullins CD, Wegener ST, Firoozabadi R, Haut ER, Bosse MJ, Seymour RB, Holden MB, Gitajn IL, Goldhaber SZ, Eastman AL, Jurkovich GJ, Vallier HA, Gary JL, Kleweno CP, Cuschieri J, Marvel D, Castillo RC; METRC. PREVENTion of CLots in Orthopaedic Trauma (PREVENT CLOT): a randomised pragmatic trial protocol comparing aspirin versus low-molecular-weight heparin for blood clot prevention in orthopaedic trauma patients. BMJ Open. 2021;11:e041845.
- https://pubmed.ncbi.nlm.nih.gov/33762229/
- URL
- O'Hara N, Degani Y, Marvel D, Wells D, Mullins CD, Wegener S, Frey K, Joseph T, Hurst J, Castillo R, O'Toole R on behalf of PREVENT CLOT Stakeholder Committee. Which Orthopaedic Trauma Patients are Likely to Refuse to Participate in a Clinical Trial? A Latent Class Analysis. BMJ Open. 2019;9:e032631.
- https://pubmed.ncbi.nlm.nih.gov/31604788/
- URL
Posters
- Risk-Stratified Thromboprophylaxis Effects of Aspirin Versus Low-Molecular-Weight Heparin in Orthopaedic Trauma Patients
- Patient Satisfaction and Out-of-Pocket Costs Associated with Aspirin and Low-Molecular-Weight Heparin: A Secondary Analysis of the PREVENT CLOT study